Yuzhou has supported the coexistence of two systems, military and civil, since the Hongwu period of the Ming Dynasty. The juxtaposition of Zhou and Wei represented the clash between agricultural and nomadic civilizations and epitomized the parallel military and administrative-territorial management systems of the Ming Dynasty, which had a profound and lasting impact on the spatial layout and architectural patterns of Yuzhou. The ancient city underwent significant changes as a result of the Zhou and Wei juxtaposition, evolving from a military town along the Great Wall to a center of commerce and trade along the Zhangku trade route. The dominant inhabitants of the city changed from officers and soldiers to civil officials to merchants, and the distribution of the city’s residential areas also changed from the Ming Dynasty. The military and civilians once resided in the southern part of the city to the east and west, but merchants gradually expanded to the outer city northwest during the Qing Dynasty. As a result, Yuzhou can be divided into five subdistricts: the Eastern Inner City, Western Inner City, Western Outer City, Central Outer City, and Northern Outer City, to summarize the spatial patterns of dwellings in each sub-district and their evolution over time. The spatial patterns of homes in the other four districts differ, with the exception of the northern part of the outer city, where the sample of dwellings is insufficient for verification.